Essays about: "oligonucleotides"
Showing result 6 - 10 of 24 essays containing the word oligonucleotides.
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6. Non-coding RNAs as therapeutic agents : The future of therapy
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Non-coding RNA (ncRNA) therapeutics are based on short oligonucleotides, both naturally occurring and artificial, which target RNA in a site-specific way to modulate gene expression. As of today, 12 synthetically produced ncRNA-based drugs are available on the market in the US and Europe, and there is a possibility of more to be approved in the near future. READ MORE
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7. Comprehensive Study on Aptamers and Aptamer-based Assays
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Antibodies are the gold standard molecular recognition elements and a cornerstone of molecular biology. They are used in immunoassays to precisely measure a specific analyte, but certain targets are especially challenging. Difficult targets include small molecules and molecules that do not induce an immune response. READ MORE
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8. A study of the adsorption isotherms of Ion-pair reagents
University essay from Karlstads universitetAbstract : In this project, the optimization of obtaining adsorption isotherms for the ion pair reagent, tributylamine was tested. The goal was to have a better understanding of the chromatographic process when separating biomolecules, such as oligonucleotides. READ MORE
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9. Preparative chromatographyfor modified oligonucleotides : Method development for modified oligonucleotides, fromanalytical to preparative chromatography
University essay from Karlstads universitetAbstract : Synthetic oligonucleotides, which are short strings of DNA or RNA, are a grooving area of importance for the pharmaceutical industry and for companies that manufacture diagnostic components. The manufacturing process of synthetic oligonucleotides involves many complex processes that use separation and purification techniques like ion-exchange chromatography, ion-pair reversed phase chromatography and ultra-performance liquid chromatography. READ MORE
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10. The impact of various chromatographic conditions on the separation of modified and unmodified oligonucleotides
University essay from Karlstads universitetAbstract : In this study, the effects of certain chromatographic conditions on various modified and unmodified oligonucleotides were investigated. At the forefront of this study was the investigation of a new Ion-pair Reversed-phase liquid chromatography (IP-RPLC) method, that had the potential to replace a previously established triethylammonium acetate (TEAA) IP-RPLC method developed for oligonucleotide separations. READ MORE