Essays about: "pentameric ligand-gated ion channels"

Found 5 essays containing the words pentameric ligand-gated ion channels.

  1. 1. Approaches to Structural Characterization of a Heteromeric GABA(A)R

    University essay from KTH/Tillämpad fysik

    Author : Alexander Stevens; [2023]
    Keywords : Applied Physics; Biophysics; Molecular Biophysics; GABA A R; LGIC; pLGIC; Tillämpad Fysik; Biofysik; Molekylär Biofysik; GABA A R; LGIC; pLGIC;

    Abstract : Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. READ MORE

  3. 2. Modulation of a model ligand-gated ion channel by amphetamine derivatives

    University essay from Uppsala universitet/Strukturbiologi

    Author : Emelia Karlsson; [2022]
    Keywords : pentameric ligand-gated ion channels; sTeLIC; electrophysiology; psychostimulants; amphetamine derivatives;

    Abstract : Pentameric ligand-gated ion channels are critical mediators of electrochemical signal transduction in neurons and other excitable cells, causing them to be important targets of psychoactive drugs. Structural data for these complex proteins are limited, particularly among eukaryotic family members and for the functionally critical open state. READ MORE

  4. 3. Extraction of gating mechanisms from Markov state models of a pentameric ligand-gated ion channel

    University essay from KTH/Proteinvetenskap

    Author : Dimitrios Karalis; [2021]
    Keywords : GLIC; Markov state models MSMs ; KL divergence; Machine Learning ML ; pentameric ligand-gated ion channel pLGIC ; channel gating;

    Abstract : GLIC är en pH-känslig pentamerisk ligandstyrd jonkanal (pLGIC) som finns i cellmembranet hos prokaryoten Gloeobacter violaceus. GLIC är en bakteriell homolog till flera receptorer som är viktiga i nervsystemet hos de flesta eukaryotiska organismer. READ MORE

  5. 4. Characterization of Alcohol Modulation of a Pentameric Ligand-gated Ion Channel with Electrophysiology and Molecular Dynamics Simulations

    University essay from KTH/Tillämpad fysik

    Author : Sabina Gutheim; [2021]
    Keywords : Biophysics; Electrophysiology; MD simulations; Ligand-gated ion channels; GLIC; Ethanol modulation; Biofysik; Elektrofysiologi; MDsimuleringar; Pentameriska ligandstyrda jonkanaler; GLIC; Etanolmodulering;

    Abstract : Pentameric ligand-gated ion channels (pLGICs) are membrane receptors that play a crucial role in every living organism. The pLGIC protein structure forms a pore through the membrane of a cell that can let specific ions pass through, upon activation by endogenous agonists. READ MORE

  6. 5. Structural basis of modulation by pH and calcium in a ligand-gated ion channel

    University essay from KTH/Genteknologi

    Author : Olivia Andén; [2021]
    Keywords : Pentameric ligand-gated ion channels; bacterial homolog; protein expression; protein purification; cryo-electron microscopy; data processing; protein structure; Pentamerisk ligandstyrd jonkanal; bakteriell homolog; proteinexpression; proteinrening; kryo-elektronmikroskopi;

    Abstract : Pentameriska ligandstyrda jonkanaler (pLGICs) är avgörande för omvandlingen av kemisk till elektrisk signalöverföring i djurs nervsystem. Dysfunktion i dessa kanaler har visat sig vara kopplad till flera sjukdomar inklusive epilepsi, schizofreni, Alzheimers och autism, vilket gör dem till en måltavla för en mängd olika läkemedel. READ MORE