Essays about: "peptides"

Showing result 1 - 5 of 84 essays containing the word peptides.

  1. 1. An investigation of the interactions between clay nanoplatelets in the presence of monovalent and divalent salts, as well as cationic peptides utilising atomistic molecular dynamics

    University essay from Lunds universitet/Kemiska institutionen

    Author : Mona Koder Hamid; [2020]
    Keywords : clay; molecular dynamics simulations; physical chemistry; fysikalisk kemi; theoretical chemistry; teoretisk kemi; Chemistry;

    Abstract : Clays are negatively charged nanoplatelets with a layered silicate structure. It has been observed from small angle X-ray scattering measurements, and coarse-grained molecular dynamics simulations (CG-MD) that clay nanoplatelets are able to form stacks, known as tactoids, in the presence of divalent or multivalent counterions [8, 5]. READ MORE

  2. 2. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Gustav Myhrinder; [2020]
    Keywords : Signal peptide; antibody; mammalian cell; HEK293; secretory pathway;

    Abstract : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. READ MORE

  3. 3. The anti-amyloidogenic chaperone DNAJB6 and its interaction with other chaperones

    University essay from Lunds universitet/Matematisk statistik; Lunds universitet/Kemiska institutionen

    Author : Gemma Nilsson; [2020]
    Keywords : chaperones; DNAJB6; Hsc70; Hsp110; ATP-hydrolysis; Ab42; polyQ; biochemistry; biokemi; Chemistry;

    Abstract : In order to maintain proteins’ functionality their native folding state must be preserved. Chaperones fold other proteins and DNAJ-chaperones may collaborate with Hsc70 chaperones to prevent aggregation of aggregation-prone peptides such as polyQ and Aβ42, which form fibrils in currently incurable diseases as Huntington’s and Alzheimer’s, respectively. READ MORE

  4. 4. A study on the manufacturing of individual-specific antigen peptides and key challenges from a GMP perspective

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Linnea Johansson; [2020]
    Keywords : cancer vaccine; peptides; neoantigen; regulatory guidelines; personalised medicine;

    Abstract : Cancer is a global health issue and is estimated to be the second leading cause of death worldwide. Within cancer treatment, it has become attractive to introduce precision medicine to harness the body’s own immune system to fight cancer. READ MORE

  5. 5. Aqueous self-assembly behaviour alteration derived from primary structure changes of model peptides

    University essay from Lunds universitet/Kemiska institutionen

    Author : Marcus Bäcklund; [2020]
    Keywords : Model peptides; self-assembly; SAXS; FTIR; CD; physical chemistry; fysikalisk kemi; Chemistry;

    Abstract : Understanding of the self-assembly behaviour of peptides is of great interest within several different areas such as neurodegenerative diseases, biotechnology, and peptide pharmaceuticals. In this work we have compared the impact on the self-assembly behaviour derived from systematic changes of the primary structure of A8K, where A denotes alanine and K lysine. READ MORE