Essays about: "pharmacodynamic modelling"

Showing result 1 - 5 of 6 essays containing the words pharmacodynamic modelling.

  1. 1. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Simon Jenner; Dennis Amphan; [2020]
    Keywords : Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

    Abstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE

  3. 2. An Investigation of Semantic Interoperability with EHR systems for Precision Dosing

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Jovia Namugerwa Mukwaya; [2020]
    Keywords : precision dosing; ontology; semantic interoperability; precision medicine;

    Abstract : In healthcare, vulnerable populations that are using medications with a narrow therapeutic index and wide interpatient PK/PD (pharmacokinetic/pharmacodynamic modelling) variability are increasing. As such, variable dosage regimens may result in severe therapeutic failures or adverse drug reactions (ADR). READ MORE

  4. 3. Re-design and improvement of animal experiments, using Bayesian methods

    University essay from Lunds universitet/Matematisk statistik

    Author : Lampros Spiliopoulos; [2019]
    Keywords : Mathematics and Statistics;

    Abstract : The pharmaceutical industry uses animal models in a variety of settings including safety, pharmacodynamic modelling and efficacy. Conventionally, a frequentist design of standard animal experiments of human asthma replication includes repeatedly running treatment groups with the exact layout, focusing on effect size rather than capturing historical data of animal responses on compounds of interest. READ MORE

  5. 4. Curve fitting with confidence for preclinical dose-response data

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Mathias Cardner; [2015-02-17]
    Keywords : pharmacodynamic modelling; efficacy study; dose–response; optimal design; model-robust design; simultaneous confidence bands; bootstrap; multiple comparisons;

    Abstract : Abstract. In the preclinical stage of pharmaceutical drug development, when investigating the medicinal properties of a new compound, there are two important questions to address. The first question is simply whether the compound has a significant beneficial effect compared to vehicle (placebo) or reference treatments. READ MORE

  6. 5. Standard two-stage and Nonlinear mixed effect modelling for determination of cell-to-cell variation of transport parameters in Saccharomyces cerevisiae

    University essay from Reglerteknik; Tekniska högskolan

    Author : David Janzén; [2012]
    Keywords : Systems biology; mathematical modelling; profile likelihood; cell-to-cell variation; STS; NONMEM; Saccharomyces cerevisiae;

    Abstract : The interest for cell-to-cell variation has in recent years increased in a steady pace. Several studies have shown that a large portion of the observed variation in the nature originates from the fact that all biochemical reactions are in some respect stochastic. READ MORE