Essays about: "pharmacokinetic models"

Showing result 1 - 5 of 16 essays containing the words pharmacokinetic models.

  1. 1. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Dylan Garamani; [2022]
    Keywords : MIDD; PBPK; QSP; PK; GUI;

    Abstract : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. READ MORE

  3. 2. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Rosa Kafey; [2022]
    Keywords : PBPK; MODELLS;

    Abstract : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. READ MORE

  4. 3. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Osama Qutishat; [2022]
    Keywords : Machine learning; pharmacometrics; Neural networks; pop-pk;

    Abstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE

  5. 4. Implementation and Evaluation of Uncertainty Estimation for Advanced Pharmacokinetic Models in DCE-MRI

    University essay from Umeå universitet/Institutionen för fysik

    Author : Jonas Höglund; [2022]
    Keywords : ;

    Abstract : The goal of this report is to develop code in Python that implements and evaluates a multivariate linear error propagation for commonly used DCE-MRI models. Two pharmoacokinetic models (PK-models) were tested; modified Kety model and two-compartment exchange model. READ MORE

  6. 5. Automatic Development of Pharmacokinetic Structural Models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alzahra Hamdan; [2022]
    Keywords : pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Abstract : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. READ MORE