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Showing result 1 - 5 of 43 essays matching the above criteria.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 2. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Johan Borg; [2023]
    Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

  4. 3. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amanda Gustafsson; [2023]
    Keywords : Technology and Engineering;

    Abstract : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). READ MORE

  5. 4. Implementation of a Conceptual Computational Model to estimate the Delay Time in Drug Delivery to reduce Medication Errors in Pediatric Emergency Care

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Maja Sandén; [2023]
    Keywords : Intravenous Infusion Pump; Compartmental Modeling; Pediatric.; Intravenös Infusions Pump; Beräkningsmodell; Pediatrik;

    Abstract : Infusion pumps are used in all departments of a hospital, in the emergency care unit as well as in pediatrics. The pumps administer intravenous medications for the purpose of helping patients to manage pain and are unfortunately not spared from emerging errors. READ MORE

  6. 5. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Rosa Kafey; [2022]
    Keywords : PBPK; MODELLS;

    Abstract : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. READ MORE