Essays about: "pharmacokinetics"

Showing result 11 - 15 of 43 essays containing the word pharmacokinetics.

1. 11. Effects of antibody labeling chemistry on assays developed for the Gyrolab immunoassay platform

   University essay from Uppsala universitet/Molekylär systembiologi

   Author : Julia Dencker; [2021]
   Keywords : Antibodies; Labeling chemistry; Site-specific labeling; Immunoassay; Gyrolab;

   Abstract : The aim of this project was to make a comparison of the effects of antibody labeling chemistries on assays developed for the Gyrolab immunoassay platform. One of the labeling techniques was a heterogenous labeling technique targeting amino groups on the antibody. READ MORE

3. 12. Comparison of Multiple Models for Diabetes Using Model Averaging

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Alex Al-Mashat; [2021]
   Keywords : pharmacometrics; population pharmacokinetics; pop-pk; pop-PK diabetes; model averaging; MA; cross-validation; cv; CV; akaike information criterion; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c; farmakometri; populationsfarmakokinetik; diabetes; model averaging; MA; cross-validation; cv; CV; akaike; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c;

   Abstract : Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. READ MORE

4. 13. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Albin Leding; [2021]
   Keywords : Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

   Abstract : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. READ MORE

5. 14. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

   University essay from KTH/Medicinteknik och hälsosystem

   Author : Simon Jenner; Dennis Amphan; [2020]
   Keywords : Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

   Abstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE

6. 15. Monitoring of patients prescribed potassium supplements

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Zuzana Hovorkova; [2019]
   Keywords : ;

   Abstract : Monitoring of patients prescribed potassium supplements Zuzana Hovorkova Degree Project 30 hp, Pharmacotherapy Department of Pharmaceutical Biosciences/Division of Pharmacokinetics and Drug Therapy Supervisor: Linden Ashfield, Examiner: Margareta Hammarlund-Udenaes Introduction: In Northern Ireland, clinical technicians have been supporting pharmacist in their work in over five decades. From initially having mainly administrative tasks, the role of pharmacy technicians has progressed to more clinical activities. READ MORE