Essays about: "pharmacology"
Showing result 1 - 5 of 15 essays containing the word pharmacology.
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1. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance
University essay from Uppsala universitet/Institutionen för farmaciAbstract : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. READ MORE
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2. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study
University essay from Uppsala universitet/Institutionen för farmaciAbstract : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. READ MORE
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3. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?
University essay from Linköpings universitet/Institutionen för fysik, kemi och biologiAbstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE
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4. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation
University essay from Uppsala universitet/Institutionen för farmaciAbstract : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. READ MORE
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5. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study
University essay from KTH/Medicinteknik och hälsosystemAbstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE