Essays about: "plasma protein binding"

Showing result 1 - 5 of 18 essays containing the words plasma protein binding.

  1. 1. Exploring IGF interactions in the context of amyotrophic lateral sclerosis

    University essay from KTH/Proteinvetenskap

    Author : Axelina Schmidt; [2023]
    Keywords : cerebrospinal fluid; plasma; insulin-like growth factors IGFs ; amyotrophic lateral sclerosis; affinity proteomics; cerebrospinalvätska; plasma; insulinliknande tillväxtfaktorer IGF ; amyotrofisk lateralskleros; affinitetsproteomik;

    Abstract : Amyotrofisk lateral skleros (ALS) är en progressiv och dödlig neurodegenerativ sjukdom som påverkar motorneuroner i både hjärnan och ryggraden. Dagens ALS forskning har ett fokus på att skapa en bättre förståelse för både sjukdomsmekanism och de metaboliska processer som bidrar till sjukdomen. READ MORE

  3. 2. Validation of anti-cytokeratin antibodies used in rapid cancer diagnostics by isoelectric focusing and QCM technology

    University essay from Uppsala universitet/Biokemi

    Author : Reneh Kostines; [2021]
    Keywords : IEF; Isoelectric focusing; QCM; Attana; Cytokeratin; Keratin; Attana; Anti-cytokeratin; cancer; UBC; IDL; epithelial carcinomas; Antibody validation; Biosensor; Biosensors;

    Abstract : Antibodies are Y-shaped proteins. In the human body, antibodies areproduced by plasma cells, mainly T and B cells which are included inthe adaptive immune system. The production of antibodies is stimulatedby antigens. The binding between an antigen-specific antibody and itsantigen can be like the interconnect between a lock and a key. READ MORE

  4. 3. Characterization of novel ZCa-based variants to investigate calcium dependent target interaction

    University essay from KTH/Proteinvetenskap

    Author : Gabriella Rossi; [2021]
    Keywords : ZCa; IgE; IL-23; recycling antibody; calcium-dependency;

    Abstract : ZCa is an engineered three-helical affinity protein that through replacement of the loop between helix two and three with an EF-hand motif has a calcium-dependent binding to its target. By using the difference of calcium concentration in the plasma and the cell along with the favorable properties of ZCa, the interest in creating therapeutics toward different diseases based on the ZCa scaffold has come about. READ MORE

  5. 4. Investigating the protein-protein Interaction between Aquaporin 4 & Calmodulin

    University essay from Lunds universitet/Kemiska institutionen

    Author : Zahraa Majhool; [2020]
    Keywords : aquaporin4 protein-protein; interaction calmodulin ; biochemistry; molecular biology; biokemi; molekylärbiologi; Chemistry;

    Abstract : Around 60 million people around the world are struggling with a traumatic brain or spinal cord injury. The swelling of the brain or spinal cord happen when the water content in the CNS increase due, infection, tumor growth or brain edema. READ MORE

  6. 5. Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma

    University essay from KTH/Tillämpad fysikalisk kemi

    Author : Leona Clarin; [2020]
    Keywords : Unbound concentration; free concentration; ultrafiltration; LC-MS MS; cefotaxime; flucloxacillin; cloxacillin; piperacillin; Fri fraktion; ultrafiltrering; LC-MS MS; cefotaxim; flukloxacillin; kloxacillin; piperacillin;

    Abstract : Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. READ MORE