Essays about: "prodrug"

Found 2 essays containing the word prodrug.

1. 1. Development of an Affibody-based Prodrug Against HER2 for Cancer Therapy

   University essay from KTH/Proteinvetenskap

   Author : Cornelia Westerberg; [2021]
   Keywords : Affibody; therapeutic protein; prodrug; affibody-based prodrug; HER2-targeted therapy;

   Abstract : Affinity proteins constitute an important category of cancer therapeutics. Owing to properties such as high target affinity and selectivity, therapeutic proteins offer more targeted therapy than small molecule drugs. The target molecules are typically proteins that are overexpressed on the surface of tumour cells, such as membrane-bound receptors. READ MORE

3. 2. Cloning, Expression and Purification of a Mutant Tomato Thymidine Kinase 1 for Crystallography

   University essay from Lunds universitet/Tillämpad biokemi

   Author : Mohamad Nesrini; [2015]
   Keywords : protein expression; protein engineering; Azidothymidine; thymidine kinase; deoxyribonucleoside kinases; nucleosides; nucleoside analog; suicide gene therapy; tillämpad biokemi; applied biochemistry; BEVS.; Technology and Engineering; Chemistry;

   Abstract : Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd). READ MORE