Essays about: "short tandem repeats"

Found 3 essays containing the words short tandem repeats.

  1. 1. Validation of a Next Generation Sequencing based method for chimerism analysis in clinical practice

    University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

    Author : Maria Högberg; [2022]
    Keywords : Devyser chimerism; fragment analysis; hematopoietic stem cell transplantation; short tandem repeats; indels;

    Abstract : Hematopoietic stem cell transplantation (HSCT) is used to treat patient with hematological diseases such as leukemia and genetic conditions such as sickle cell anemia. After HSCT the patients are supervised for signs of relapse of disease or rejection of transplanted cells. This is done by using chimerism analysis. READ MORE

  3. 2. Understanding sequence errors in analysis of short tandem repeats through optimisation of a library preparation protocol utilising unique molecular indices

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Nelly Gyllö Lind; [2022]
    Keywords : polymerase chain reaction; massively parallel sequencing; DNA analysis; short tandem repeats; DNA polymerase; unique molecular indices;

    Abstract : In the last few years massively parallel sequencing (MPS) has become important for forensic DNA analysis by providing new and broader possibilities, such as increased discrimination power for short tandem repeat (STR) analyses. An imperative part of MPS analysis is library preparation where there is a fundamental reliability on in vitro DNA polymerisation, which is prone to errors. READ MORE

  4. 3. Library construction optimization and analysis of Short Tandem Repeats by a simple, PCR-based DNA barcoding method

    University essay from Lunds universitet/Teknisk mikrobiologi; Lunds universitet/Bioteknik

    Author : Markus André Soma; [2020]
    Keywords : Forensics; DNA; Short Tandem Repeats; Unique Molecular Identifiers; Polymerase Chain Reaction; Capillary Electrophoresis; Massively Parallel Sequencing; Applied Microbiology; Teknisk mikrobiologi; Biology and Life Sciences; Technology and Engineering;

    Abstract : DNA profiling is evolving in the forensics community towards introducing massively parallel sequencing (MPS) as a complement to capillary electrophoresis (CE). Obstacles remain however before this technology can become routine in forensic casework, such as the development of more efficient bioinformatics solutions and recommendations concerning data analyses. READ MORE