Essays about: "somatropin"

Found 3 essays containing the word somatropin.

  1. 1. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Javier Lagares Martín; [2023]
    Keywords : Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Abstract : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. READ MORE

  3. 2. Effects of pharmaceutical excipients on the chemical stability of therapeutic proteins in a parenteral formulation

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Emmanuel Gulangayan Deniola; [2022]
    Keywords : Chemical stability; protein degradation; GA-Z; somatropin; pharmaceutical excipients; liquid chromatography; pharmaceutical technology; Chemistry;

    Abstract : Proteins and peptides are widely used for the prevention, management, and cure of various illnesses. This vast therapeutic potential represents a significant portion of the pharmaceutical industry in the form of vaccines, antibodies, enzymes, and other protein-based therapeutics. READ MORE

  4. 3. Aggregation mechanisms of proteins in liquid formulations

    University essay from KTH/Kemi

    Author : Amanda Hamrin; [2022]
    Keywords : Protein aggregering; seedingmekanism; dynamic light scattering; differential scanning calorimetry; Somatropin; monoklonal antikropp; Protein aggregation; seeding mechanism; dynamic light scattering; differential scanning calorimetry; somatropin; monoclonal antibody;

    Abstract : Biologiska läkemedel har under det senaste århundradet utökats, och under de senaste 25 åren så har proportionen av godkända biologiska läkemedel har ökat för behandlingen av sjukdomar, vaccin, och diagnostik. Det finns flera olika mekanismer för protein aggregering, och en av dessa är seeding, vilket innebär aggregering inducerat av tillsatta aggregat eller förekomsten av strukturförändringar i proteinet. READ MORE