Essays about: "surfactants"

Showing result 1 - 5 of 34 essays containing the word surfactants.

1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

   Author : Elina Edidovica; [2024]
   Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

   Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

3. 2. Effects of mixed surfactant system on chemical and physical stability of human growth hormone

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Karnsinee Viriyayudhakorn; [2023]
   Keywords : human growth hormone; surfactant; refolding; protein stability; physical degradation; chemical degradation; pharmaceutical technology; Technology and Engineering;

   Abstract : In protein formulation, addition of surfactants is commonly executed to enhance product stability and shelf-life. The reason is that surfactants can protect proteins against surface-induced aggregation. However, the interaction between surfactant and protein depends on the type of surfactant used. READ MORE

4. 3. Geobacillus 7349 – A new potential biosurfactant producing microorganism

   University essay from Lunds universitet/Bioteknik (master); Lunds universitet/Bioteknik (CI)

   Author : Zhuoying Deng; [2023]
   Keywords : biosurfactant; rhamnolipids; HPLC; HPAEC-PAD; bacteria growth; downstream purification; liquid-liquid extraction; biotechnology; Chemistry;

   Abstract : The main aim of this master project is to find out whether strain Geobacillus 7349 can produce biosurfactant during their growth by extraction and characterization of the product. The other goal is to optimize the cultivation condition of the strain. READ MORE

5. 4. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Javier Lagares Martín; [2023]
   Keywords : Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

   Abstract : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. READ MORE

6. 5. Filtration of oil-in-water nanoemulsions for potential adjuvant development applications

   University essay from KTH/Kemiteknik

   Author : Emilie Degeneve; [2023]
   Keywords : Filtration of oil-in-water nanoemulsions for potential adjuvant development applications; Vaccin; adjuvans; nanoemulsion; ytaktiva ämnen; filtrering;

   Abstract : I den här studien undersöktes innovativa sammansättningar för produktion av vaccinadjuvans. Syftet var att stabilisera nanoemulsioner av olja i vatten, med hjälp av squalenolja (som används inom läkemedelsindustrin), med olika ytaktiva ämnen och att testa filtrerbarheten hos dessa nanoemulsioner. READ MORE