Essays about: "tandem repeats"
Found 5 essays containing the words tandem repeats.
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1. Validation of a Next Generation Sequencing based method for chimerism analysis in clinical practice
University essay from Uppsala universitet/Institutionen för medicinsk cellbiologiAbstract : Hematopoietic stem cell transplantation (HSCT) is used to treat patient with hematological diseases such as leukemia and genetic conditions such as sickle cell anemia. After HSCT the patients are supervised for signs of relapse of disease or rejection of transplanted cells. This is done by using chimerism analysis. READ MORE
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2. Understanding sequence errors in analysis of short tandem repeats through optimisation of a library preparation protocol utilising unique molecular indices
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : In the last few years massively parallel sequencing (MPS) has become important for forensic DNA analysis by providing new and broader possibilities, such as increased discrimination power for short tandem repeat (STR) analyses. An imperative part of MPS analysis is library preparation where there is a fundamental reliability on in vitro DNA polymerisation, which is prone to errors. READ MORE
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3. Library construction optimization and analysis of Short Tandem Repeats by a simple, PCR-based DNA barcoding method
University essay from Lunds universitet/Teknisk mikrobiologi; Lunds universitet/BioteknikAbstract : DNA profiling is evolving in the forensics community towards introducing massively parallel sequencing (MPS) as a complement to capillary electrophoresis (CE). Obstacles remain however before this technology can become routine in forensic casework, such as the development of more efficient bioinformatics solutions and recommendations concerning data analyses. READ MORE
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4. Copy number variations as potential biomarkers for disease development in Breast Cancer
University essay from SLU/Dept. of MicrobiologyAbstract : Breast cancer is second foremost cause of deaths in women caused by malignant tumor.Comparing genetic profiles of cells surrounding the tumor and blood from same patient may reveal de‐novo somatic aberrations that may predispose normal cells to cancer cells. READ MORE
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5. Detection and analysis of megasatellites in the human genome using in silico methods
University essay from Institutionen för kommunikation och informationAbstract : Megasatellites are polymorphic tandem repetitive sequences with repeat-units longer than or equal to 1000 base pairs. The novel algorithm Megasatfinder predicts megasatellites in the human genome. A structured method of analysing the algorithm is developed and conducted. The analysis method consists of six test scenarios. READ MORE