Essays about: "thiopurine methyltransferase"

Found 2 essays containing the words thiopurine methyltransferase.

1. 1. In vitro studies of Thiopurine S-Methyltransferase: Ligand binding interactions and development of a new enzymatic activity assay for TPMTwt, TPMT*6 and TPMT*8

   University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi; Linköpings universitet/Tekniska fakulteten

   Author : Lovisa Hemmingsson; Johan Klasén; [2015]
   Keywords : Thiopurine S-Methyltransferase; 6-mercaptourine; methotrexate; isothermal titration calorimetry; fluorescence spectroscopy;

   Abstract : Acute lymphoblastic leukemia, one of the most malignant cancer forms in children is commonly treated with the thiopurine 6-mercaptopurine (6-MP) in combination with a high dose of methotrexate (MTX). 6-Mercaptopurine is in the body metabolized by the enzyme thiopurine S-methyltransferase (TPMT). READ MORE

3. 2. Biophysical characterization of the *5 protein variant of human thiopurine methyltransferase by NMR spectroscopy

   University essay from Molekylär Bioteknik

   Author : Robert Gustafsson; [2012]
   Keywords : thiopurine methyltransferase; hydrogen exchange; nuclear magnetic resonance; relaxation; protein dynamics; local stability;

   Abstract : Human thiopurine methyltransferase (TPMT) is an enzyme involved in the metabolism of thiopurine drugs, which are widely used in leukemia and inflammatory bowel diseases such as ulcerative colitis and Crohn´s disease. Due to genetic polymorphisms, approximately 30 protein variants are present in the population, some of which have significantly lowered activity. READ MORE