Essays about: "ubiquitin"
Showing result 1 - 5 of 17 essays containing the word ubiquitin.
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1. Imaging of the Cytosolic Antibody Receptor TRIM21
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : TRIM21 is a cytosolic ubiquitin ligase and an antibody receptor that providesa last line of defense against invading pathogens. By utilizing the diversity ofantibody repertoire to identify pathogens, TRIM21 serves as a link betweenintrinsic cellular defense and adaptive immunity. READ MORE
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2. Polarizability and Orientation Dynamics of Small Proteins
University essay from Uppsala universitet/MaterialteoriAbstract : Proteins often carry an intrinsic electric dipole moment, which can interact with external electric fields and cause protein motion. Previous research has found that the orientation of small proteins in gas phase can be controlled in a static electric field. READ MORE
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3. The effect of water on the orientation of a protein in an electric field
University essay from Uppsala universitet/Institutionen för fysik och astronomiAbstract : Structure determination of proteins is vital for the understanding of their function. It often relies on techniques that use intense X-ray pulses to create diffraction patterns of protein crystals, which then contain information on the three-dimensional structure of the crystallised protein. READ MORE
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4. Sustaining Orientation of Ubiquitin for Single Particle Imaging Using Electric Fields
University essay from Uppsala universitet/Kemisk och biomolekylär fysik; Uppsala universitet/Energimaterialens fysikAbstract : Single-particle imaging, or SPI, is a method used to obtain the three-dimensional structure of particles. Repeatedly aiming X-rays at samples of a particle produces diffraction patterns, which are combined to a best-fit three-dimensional model of the particle. SPI of proteins can be improved by orienting the protein before imaging. READ MORE
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5. Development of biophysical methods for characterization of PROTACs
University essay from Uppsala universitet/BiokemiAbstract : Targeting protein with the aim of ubiquitin-labelling for degradation is a new and upand coming field of drug discovery. Proteolysis targeting chimeras (PROTACs) areheterobifunctional linker molecules that connects the target molecule to an E3ubiquitin ligase, subsequent ubiquitination of the target protein initiates the proteindegradation by the proteosome system. READ MORE