A pericyte-specific knockout of Foxf2 in mice shows fibrinogen acculumation in the brain but no regulation in Pdgfr-ß expression

Abstract: FoxF2 is a transcriptional factor that initiates gene expression. Foxf2 is particularly expressed in central nervous system pericytes. Recent studies have displayed that an inactivation of Foxf2 in mice had an impact on the blood-brain barrier integrity with evidence of breakdown. During angiogenesis, the protein pdgf-B is synthesized by endothelial cells and is detected by pdgfr-