Automated Inference of Excitable Cell Models as Hybrid Automata.

Abstract: In this paper, we explore from an experimental point of view the possibilities and limitations of the new HYCGE learning algorithm for hybrid automata. As an example of a practical application, we study the algorithm’s performance on learning the behaviour of the action potential in excitable cells, specifically the Hodgkin-Huxley model of a squid giant axon, the Luo-Rudy model of a guinea pig ventricular cell, and the Entcheva model of a neonatal rat ventricular cell. The validity and accuracy of the algorithm is also visualized through graphical means.