Polystyrene nanoparticles interactions with Calbindin D9k and Monellin
Abstract: Nanomedicine and the use of nanoparticles (NPs) are growing like never before. It is therefore important to investigate the interactions in the nano world and the possible hazards. Proteins in organisms can adsorb to NPs and change the proteins structure and therefore their functions. This could be a potential danger and thus an interesting research field. Here, we explore how the proteins Calbindin D9k and Monellin interacts with polystyrene NPs using fluorescence spectroscopy and NPs colloidal stability using dynamic light scattering (DLS). We show that similar charges repel and the opposite attract proteins to NPs, proteins hydrophobic patches allow them to adsorb to hydrophobic NPs and the size of the NPs seems to affect how fast the proteins adsorbs to the NPs.
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