University essay from Lunds universitet/Matematik LTH

Author: Lisa Wikman; [2020]

Keywords: Technology and Engineering;

Abstract: Calcification of the mitral and aortic valves is one of the main precursors to heart valve diseases. Calcified valves and coronary vessels is also an indication of risk for future cardiac events such as cardiac infarct(1)(2). During this master thesis project, a program for automatic identification and quantification of calcium in the mitral and aortic valves in CT image stacks was implemented. The program can differentiate between the aorta valve and the mitral valve and give separate scores for the valves as well as a total score which is the sum of the mitral and aorta score. The program is based on image analysis and reached a sensitivity of 100 % and a specificity of 85.4 % when the limit ≥ 100 Agatston units was used for identifying patients at risk in a comparison of 49 cases with the existing manual program syngo.via. The program can automatically go through and identify calcium in a large amount of data, and due to the high prevalence of noise it is also possible to manually go back and check and rescore images if desired.

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