Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

Abstract: Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. Population PK models are frequently described by non-linear mixed effect (NLME) models, that including both random and fixed effect components. The fixed effect components