Neurotransmitter MIPs for the Potential Use in Amperometric Sensors

University essay from Lunds universitet/Tillämpad biokemi

Abstract: Molecular imprinting technology is a field where polymer technology is utilised to synthesise high affinity particles, much like antibodies. This project has dealt with the imprinting of the neurotransmitter molecules serotonin and histamine. Serotonin polymers were synthesised using methacrylic acid and acrylamide as functional monomers relying on hydrogen bonding for the imprinting effect. None of the produced batches showed any sign of imprinting. Instead histamine polymers were successfully synthesised showing specific binding with the average binding affinity Kd = 0:61 mM and the approximate number of binding sites N = 50 μmolg

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