Microalbuminuria, blood pressure and cardiovascular risk factors in elderly males

University essay from Institutionen för medicinsk biokemi och mikrobiologi; Enheten för klinisk näringsforskning; Institutionen för medicinska vetenskaper

Author: Gösta Florvall; Samar Basu; Johanna Helmersson; Anders Larsson [2005]

Keywords: C-reactive protein; Humans; Hypertension; IL-6; Inflammation; Lipids; Microalbuminuria; SAA; Smoking; Vascular disease;

Abstract: Objective - To correlate blood pressure and inflammatory markers with urine albumin analysed with a point-of-care testing (POCT) instrument, nephelometric determination of albumin and creatinine related urine albumin in elderly males. Methods and Results - The study population consisted of 103 diabetic and 603 nondiabetic males (age 77 years) in a cross-sectional study in central Sweden. We analyzed urine albumin with a HemoCue® Urine Albumin POCT instrument and a ProSpec® nephelometer and creatinine related urine albumin. There were strong correlation between both systolic and diastolic blood pressure and all three urine albumin methods (p<0.0001). There were also significant correlations between the different urine albumin measurements and SAA, hsCRP and IL-6. Conclusions - Hypertension has a strong impact on hyperfiltration in diabetic and nondiabetic elderly males.

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