Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)

University essay from Uppsala universitet/Cancerfarmakologi och beräkningsmedicin

Author: Joel Ås; [2016]

Keywords: ;

Abstract:

This master thesis studies the potential benefit of iterative selection of the concentrations

evaluated when building mathematical dose-response curves (and response surfaces when

there are two drugs) using experimental measurements. The reference alternative is to use

a standard two-fold dilution series or ten-fold dilution series measured in replicates. The

standard 4-parameter Hill dose-response model is used as a reference and for simulations.

Models to screen for synergy between two different substances are also developed in this thesis.

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