Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)
This master thesis studies the potential benefit of iterative selection of the concentrations
evaluated when building mathematical dose-response curves (and response surfaces when
there are two drugs) using experimental measurements. The reference alternative is to use
a standard two-fold dilution series or ten-fold dilution series measured in replicates. The
standard 4-parameter Hill dose-response model is used as a reference and for simulations.
Models to screen for synergy between two different substances are also developed in this thesis.
AT THIS PAGE YOU CAN DOWNLOAD THE WHOLE ESSAY. (follow the link to the next page)