Method development and applications - hollow fiber SLM extraction of mono and dicarboxylic acids
Abstract: A highly sensitive (LOD= 0.04-0.4 ng/ml) method was developed for the detection and quantification of monocarboxylic and dicarboxylic acids (C3 -C10) by GC-MS. These compounds exist in trace amount as essential components of secondary organic aerosols i.e. they are important constituents of atmospheric aerosols. Membrane extraction technique was utilized for selective enrichment (1-4300 times) of the target compounds. Good repeatability (RSD% ≤ 10%) using a selective organic phase (10% TOPO in DHE) was achieved with three-phase HF-LPME. Target compounds in real samples (aerosols), after ultrasonic assisted extraction were quantified through GC-MS. Effective derivatization of each target compound was performed with BSTFA reagent. Gas chromatography, having a capillary column and interfaced with mass spectrometry was used for detection, separation and quantification of the target compounds.
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