Essays about: "gamma-secretase"

Found 2 essays containing the word gamma-secretase.

  1. 1. Molecular studies of the γ-secretase complex activity and selectivity towards the two substrates APP and Notch

    University essay from Akademin för hållbar samhälls- och teknikutveckling

    Author : Ilyas Bakir; [2010]
    Keywords : Alzheimer’s disease; APP; γ-secretase; gamma-secretase; β-amyloid peptide; APP intracellular domain; Notch; Ilyas Bakir;

    Abstract : Alzheimer Disease (AD) is the most common neurodegenerative disorder in the world. One of the neuropathological hallmarks of AD is the senile plaques in the brain. The plaques are mainly composed of the amyloid β (Aβ) peptide. READ MORE

  3. 2. Studies on potential APC/β-catenin target genes in the Notch pathway

    University essay from Institutionen för fysik, kemi och biologi

    Author : John Grünberg; [2009]
    Keywords : Notch; Wnt; APC; β-catenin; Colorectal cancer; HT29; LEF1 Tcf;

    Abstract : Both Notch and the Wnt pathways are key regulators in maintaining the homeostasis in the intestine. Defects on the key tumor suppressor adenomatous polyposis coli, APC a gene in the Wnt pathway is most frequently mutated in colorectal cancer. Previous studies have indicated that there is a crosstalk between these two pathways. READ MORE