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Showing result 1 - 5 of 13 essays matching the above criteria.

  1. 1. Effects of Persistent Organic Pollutants and Their Mixtures on Biotransformation and Oxidative Stress in Zebrafish Embryo

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Hyon Sun Jeong; [2016]
    Keywords : Zebrafish; Developmental toxicity; Mixture toxicity; Oxidative stress;

    Abstract : Persistent organic pollutants (POPs) cause significant effects on organisms due to their resistance to environmental degradation and specific toxic responses. Although POPs toxicities were linked to oxidative stress in the previous studies, there are few POPs studies that link them with oxidative stress in zebrafish during development. READ MORE

  3. 2. Assay of nitrification potentials in sewage sludge : development and evaluation of method, and nitrification potentials in sewage sludge before and after application to soil

    University essay from SLU/Dept. of Microbiology

    Author : Caroline Jöngren; [2016]
    Keywords : Sewage sludge; nitrification potentials; PAO; sanitations treatment; ammonium; storage treatments; nitrous oxide; Nitobacteriacea; Nitrosomona;

    Abstract : Sewage sludge (SS) contains valuable plant nutrients applicable to soil as fertilizer. Application to arable land is though controversial as SS can contain contains such as human pathogens, heavy metals and xenobiotics. READ MORE

  4. 3. MDR1-mutationen hos hundar

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Johanna Olsson; [2015]
    Keywords : P-glykoprotein; MDR1; mutation; hund; makrocykliska laktoner; P-glycoprotein; dog; macrocyclic lactones;

    Abstract : P-glykoprotein (P-gp) är en effluxtransportör som ursprungligen uppmärksammades för sin kapacitet att skydda tumörceller från flertalet läkemedel. Det har sedan visat sig att P-gp även finns i andra vävnader, som tarm, njurtubuli, lever samt i hjärnans kapillära endotelceller. READ MORE

  5. 4. Thyroid Endocrine Disruption of Propylparaben Assessed Using an Optimized Individual Xenopus tropicalis Metamorphosing Tadpole Exposure System

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Johannes Pohl; [2015]
    Keywords : Xenopus; Thyroid hormones; Endocrine disruption; Amphibian metamorphosis assay; Propylparaben; Hormonstörande ämnen; Propylparaben; Xenopus; Sköldkörtelhormoner;

    Abstract : The anuran Xenopus tropicalis tadpole is an attractive model animal in toxicological evaluation of suspected thyroid disrupting xenobiotics. Due to its reliance of a functioning hypothalamic-pituitary-thyroid (HPT) axis for normal metamorphosis, effects on the HPT axis produces apical endpoints, which are easy to measure. READ MORE

  6. 5. Building predictive unbound brain-to-plasma concentration ratio (Kp,uu,brain) models

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Srinidhi Varadharajan; [2014]
    Keywords : Biology and Life Sciences;

    Abstract : Abstract The blood-brain barrier (BBB) constitutes a dynamic membrane primarily evolved to protect the brain from exposure to harmful xenobiotics. The distribution of synthesized drugs across the blood-brain barrier (BBB) is a vital parameter to consider in drug discovery projects involving a central nervous system (CNS) target, since the molecules should be capable of crossing the major hurdle, BBB. READ MORE