Exploring adaptation of self-supervised representation learning to histopathology images for liver cancer detection

Abstract: This thesis explores adapting self-supervised representation learning to visual domains beyond natural scenes, focusing on medical imaging. The research addresses the central question: "How can self-supervised representation learning be specifically adapted for detecting liver cancer in histopathology images?" The study utilizes the PAIP 2019 dataset for liver cancer segmentation and employs a self-supervised approach based on the VICReg method. The evaluation results demonstrated that the ImageNet-pretrained model achieved superior performance on the test set, with a clipped Jaccard index of 0.7747 at a threshold of 0.65. The VICReg-pretrained model followed closely with a score of 0.7461, while the model initialized with random weights trailed behind at 0.5420. These findings indicate that while ImageNet-pretrained models outperformed VICReg-pretrained models, the latter still captured essential data characteristics, suggesting the potential of self-supervised learning in diverse visual domains. The research attempts to contribute to advancing self-supervised learning in non-natural scenes, provides insights into model pretraining strategies, and introduces novel non-linear data augmentation techniques.