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1. 1. Can the selective PDGF-receptor antagonist STI571 reduce hypoxia in solid tumors, and enhance drug uptake of Taxol, by lowering the interstitial fluid pressure in stroma rich breast carcinoma, BT-474

   University essay from Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

   Author : Marcus Runeson; [2015]
   Keywords : ;

   Abstract : Background Solid tumors have high interstitial fluid pressure, IFP. This cause a dramatic loss in uptake of anti cancer drugs with poor clinical outcome as result. Treatment with PDGF-receptor antagonist STI-571 lowers tumor IFP and enhances uptake of small compounds. READ MORE