Essays about: "Monoclonal Antibodies mAbs"

Showing result 1 - 5 of 12 essays containing the words Monoclonal Antibodies mAbs.

  1. 1. OPTIMIZATION OF CLONE SELECTION PLATFORM FOR PRODUCTION OF RECOMBINANT PROTEINS

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Basel Yousef; [2024]
    Keywords : ;

    Abstract : Background  Biologics are type of proteins that can be produced by expression in a foreign host for medical healthcare applications in humans. Monoclonal antibodies (mAbs) are type of biologics that are designed to specifically bind to one target, with a purpose to inhibit a certain molecule that could be associated with a disease process. READ MORE

  3. 2. Identification of Monoclonal Antibodies:Peptide Mass Fingerprinting (PMF) with Matrix Assisted Laser Desorption/Ionization (MALDI), Time of Flight (ToF), Mass Spectrometry (MS) and Protein Peptide Mapping (PPM) with Capillary Electrophoresis (CE)

    University essay from KTH/Proteinvetenskap

    Author : Sofia Bengtsson; [2023]
    Keywords : Monoclonal Antibodies mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Capillary Gel Electrophoresis CGE ; Capillary Zone Electrophoresis CZE ; Monoklonala antikroppar mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Kapillärgelelektrofores CGE ; Kapillärzonelektrofores CZE ;

    Abstract : Antalet monoklonala antikroppar som används i läkemedel ökar kraftigt. Dessa läkemedel är dyra och risken för förfalskning är stor. Behovet att utveckla en metod för snabb och precis identifiering av monoklonala antikroppar är därför brådskande. READ MORE

  4. 3. Simulation of periodic counter-current chromatography purification of monoclonal antibodies with column degradation

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Erik Friberg; [2022]
    Keywords : Counter-current chromatography; PCC; Monoclonal antibodies; Affinity chromatography; Process control; Chemical engineering; Process simulation; Chemistry;

    Abstract : The purification process of monoclonal antibodies (mAbs) for therapeutic drugs is expensive, especially the chromatography step in which the mAbs are separated from other proteins and cells present in the feed. The antibodies are separated from the feed using affinity chromatography, where only the antibodies interact with active sites within the column, whereas the rest passes through the column without stopping. READ MORE

  5. 4. Optimization of immunotherapeutic relevant ABD-derived affinity proteins for prolonged serum half-life

    University essay from KTH/Proteinvetenskap

    Author : Ebba Bergström; [2022]
    Keywords : Half-Life extension; Human serum Albumin HSA ; Interleukin 17c IL17c ; ABD-Derived Affinity ProTeins ADAPT ; Protein-based drugs.;

    Abstract : Marknaden för proteinbaserade läkemedel, de så kallade biologiska läkemedlen, är idag en industri som omsätter miljarder. Ett vanligt sätt att utveckla dessa läkemedel på är med hjälp av monoklonala antikroppar då de kan binda till sitt mål med hög specificitet. READ MORE

  6. 5. Development of a high-throughput platform for generation and early screening of high producing stable cell lines

    University essay from KTH/Proteinvetenskap

    Author : Jonathan Karlsson Persson; [2021]
    Keywords : CHO-K1; HEK293; CellCelector™; High-throughput screening; Protein A beads; Secondary antibody; CHO-K1; HEK293; CellCelector™; Högkapacitets-screening; Protein A-kulor; Sekundär antikropp;

    Abstract : Produktionen av rekombinanta biofarmaceutiska läkemedel, exempelvis monoklonala antikroppar, är en oumbärlig men ansträngande process. Under 2019 var sju av de tio mest sålda läkemedlen globalt baserade på rekombinant producerade monoklonala antikroppar. READ MORE