Essays about: "Verapamil"

Found 4 essays containing the word Verapamil.

  1. 1. Models for predicting efflux transport over the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Marjaneh Janani; [2020]
    Keywords : efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

    Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

  3. 2. Models for predicting efflux transport over the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Marjaneh Janani; [2020]
    Keywords : Efflux; blood-brain-barrier; modeling; transporter;

    Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE

  4. 3. Modelling and robust estimation of AV node function during AF

    University essay from Lunds universitet/Avdelningen för Biomedicinsk teknik

    Author : Gennaro Garoldi; Luca Iozzia; [2014]
    Keywords : Atrial Fibrillation AF ; atrioventricular node AV node ; Carvedilol; Diltiazem; dual pathways; Holter recordings; maximum likelihood estimation MLE ; minimum least squares MLS ; metoprolol; refractory period; RR intervals; statistical modeling; Verapamil.; Technology and Engineering;

    Abstract : Objective: The purpose of the present thesis is to enrich the robustness of a statistical atrioventricular (AV) node model during atrial Fibrillation (AF). The model takes into account electrophysiological properties as the two pathways, their refractory periods and concealed conduction; these pathways are located between sinoatrial (SA) and AV node. READ MORE

  5. 4. The toxicological evaluation of Sewage Effluents and Pharmaceuticals with the use of Zebrafish as a model organism

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Motunrayo Ganiyat Akande; [2008]
    Keywords : Zebrafish; Danio rerio; pharmaceuticals; reproduction test; fish sexual ; development test; fish embryo toxicity test; vitellogenin;

    Abstract : The presence of pharmaceuticals in the environment has been an issue of increasing concern and sewage treatment plants have been identified as the principal sources ofpharmaceuticals and endocrine disrupting chemicals in the aquatic environment.In this study, zebrafish juveniles and adults were exposed to sewage effluents that had undergone treatment processes (A1-A7) at Hammarby Sjostad’s sewage treatment plant in order to evaluate the effectiveness of the treatment processes. READ MORE