Essays about: "active protease inhibitors"

Found 4 essays containing the words active protease inhibitors.

  1. 1. Studies of broad-spectrum inhibitors against main protease of SARS-CoV-2 and other Coronaviruses

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Alexandra Stanciu; [2023]
    Keywords : human coronavirus 229E; SARS-CoV-2; main protease; nirmatrelvir; GC-376; compound 19;

    Abstract : Coronaviruses have caused three large outbreaks in the past century. The most recent one, also still ongoing, is represented by the SARS-CoV-2/Covid-19 pandemic. Efforts have been taken to develop efficient vaccines and antivirals and one of the major virus-based targets in drug development is represented by the main protease of these viruses. READ MORE

  3. 2. In Vitro Assessment of Novel Compounds as Potential Pan-Coronavirus Therapeutics in SARS-CoV-2 and In Vitro Assessment of a Pan-Flavivirus Compound in Zika Virus

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Julia Berger; [2022]
    Keywords : Human coronavirus; active protease inhibitors; drug discovery; 3CLpro; Zika virus; flavivirus inhibitor; NS2B-NS3;

    Abstract : Through the SARS-CoV-2 pandemic, it has become clear that the development of antivirals is essential for the health and wellbeing of the population. In this study, novel active site protease inhibitors against SARS-CoV-2 were tested for their inhibitory activity against the viral 3-Chymotrypsin like protease through the means of FRET based enzymatic assays. READ MORE

  4. 3. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Elin Öberg; [2022]
    Keywords : x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Abstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE

  5. 4. Kinetic studies of serine protease inhibitors in 'active barrier' model systems

    University essay from Uppsala universitet/Institutionen för kemi - BMC

    Author : Cecilia Ålander; [2015]
    Keywords : ;

    Abstract : .... READ MORE