Essays about: "biological drugs"

Showing result 1 - 5 of 44 essays containing the words biological drugs.

  1. 1. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

    University essay from Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Author : Erik Everett Palm; [2023]
    Keywords : bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

    Abstract : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. READ MORE

  3. 2. Predicting morphological effect of compounds on COVID-19 infected cells

    University essay from Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Author : Viktor Öhrner; [2023]
    Keywords : QSAR; ML; AI; bioinformatics; COVID-19; morphological profiles;

    Abstract : The cost of developing new drugs is high and the aim of computer-assisted drug discovery is to reduce that development cost, either through virtual screening or generating novel compounds. System biology is one approach to drug discovery where the response of a biological system is the subject of study, instead of drug target interaction. READ MORE

  4. 3. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Johan Thorsson; [2023]
    Keywords : Biology and Life Sciences;

    Abstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE

  5. 4. Panacea: Predicting anti-aging combinations from expression analysis

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Ashwini Jatti; [2023]
    Keywords : aging; machine learning; drug combinations; rejuvenation; cellular reprogramming;

    Abstract : Identifying interventions, such as drugs, that can counteract the effects of aging is crucial due to the complex nature of the aging process, which involves multiple biological processes. By targeting these processes, interventions have the potential to promote healthy aging. READ MORE

  6. 5. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    University essay from Lunds universitet/Kemiska institutionen

    Author : Simon Gripvall; [2023]
    Keywords : biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Abstract : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. READ MORE