Essays about: "cell cycle arrest"

Showing result 1 - 5 of 15 essays containing the words cell cycle arrest.

  1. 1. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma

    University essay from KTH/Proteinvetenskap

    Author : Alexandra Johannesson; [2023]
    Keywords : neuroblastoma; doxorubicin; gemcitabine; targeted drugs; ATM; neuroblastom; doxorubicin; gemcitabin; målinriktade läkemedel; ATM;

    Abstract : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. READ MORE

  3. 2. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Johan Thorsson; [2023]
    Keywords : Biology and Life Sciences;

    Abstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE

  4. 3. Toxicological analysis of Pyraclostrobin and Cyprodinilon Zebrafish larvae

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Kim Yeju; [2022]
    Keywords : gene expression; mixture effect; toxicity; pesticides; stress response;

    Abstract : Cyprodinil and pyraclostrobin are widely used pesticides to protect many plants from attack of microorganisms and fungal diseases. Although cyprodinil and pyraclostrobin exist in the aquatic environment at low concentration, their leftovers in the ecosystems lead to oxidative damage and interfere development in aquatic animals at environmental-relevant concentration. READ MORE

  5. 4. Combination of Antimetabolites with Chemotherapy as a Novel Treatment Option in High-risk Neuroblastoma

    University essay from KTH/Proteinvetenskap

    Author : Maja Lundström; [2022]
    Keywords : cell cycle arrest; chemotherapy resistance; combination therapy; cytarabine; doxorubicin; gemcitabine;

    Abstract : 20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall. Subpopulationer av resistenta celler har identifierats i hög-risk NB-cellinjer, vilket belyser behovet av nya behandlingsalternativ. READ MORE

  6. 5. Effect of Ion Channels on Intracellular Localization of REV-ERBα in Glioma-Initiating Cells

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Selay Oba; [2021]
    Keywords : cancer; childhood cancer; glioblastoma multiforme; GBM; SR9009; mibefradil; REV-ERBα;

    Abstract : The number of children and young adolescents diagnosed with cancer is increasing, leading to a need for new therapeutic strategies with diminished neurodegenerative side- effects. This report presents preliminary observations on glioma-initiating cells (GICs) in the way to develop a strategy that induces cell-cycle arrest or quiescence in neural stem cells (NSCs). READ MORE