Essays about: "renal cancer"

Showing result 1 - 5 of 7 essays containing the words renal cancer.

  1. 1. Ouabain Toxicity -Selectivity Towards Renal Cancer Cells

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Emma Magnusson; [2020]
    Keywords : Cardiotonic steroids; ouabain; Na K -ATPase; cytotoxicity; renal cancer; apoptosis; Kardiotoniska steroider; ouabain; Na K -ATPase; cytotoxicitet; njurcancer; apoptos;

    Abstract : Ouabain and other cardiotonic steroids are known to inhibit Na + ,K + -ATPase (NKA), theion pump responsible for the ionic gradient across the plasma membrane. These steroidsdisplay a selective toxicity towards several tumour cells in comparison to primary humancells, however, the mechanism behind this is not yet understood. READ MORE

  3. 2. The Influence of 3D Cell Organization in Tumor Spheroid on Natural Killer Cell Infiltration and Migration

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Luigi Morrone; [2020]
    Keywords : Natural Killer Cells; Tumor Spheroids; Fluorescence Microscopy; Infiltration; Migration; Killing;

    Abstract : Natural Killer cells are a type of lymphocyte belonging to the innate immune system and they operate cell-mediated cytotoxicity and release of pro-inflammatory cytokines against cancerous cells. However, in vivo testings have shown a reduced activity of NK cells against solid tumors probably due to the negative influence of the immunosuppressive tumor microenvironment. READ MORE

  4. 3. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Jesper Borin; [2020]
    Keywords : ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

    Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE

  5. 4. Patient-derived organoid culture for 3D culture of colorectal cancer, renal cancer and osteosarcoma

    University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Author : Seiko Johansson; [2019]
    Keywords : FMCA; Anticancer drugs; Survival index; BME-gel; VEGF;

    Abstract : It is always important to choose appropriate anticancer drugs for cancer patients. At RCL, a division of Uppsala university hospital, drug resistance profiles of patients are evaluated by a cell viability assay called FMCA. READ MORE

  6. 5. Cytokine-induced immune cell migration towards tumour cells in a microchip environment

    University essay from KTH/Skolan för teknikvetenskap (SCI)

    Author : Wiktor Nilsson; Emil Andersson; [2016]
    Keywords : ;

    Abstract : The purpose of this project was to study the migration patterns of human immune cells in response to human renal cancer cells. This is useful in the study of different cancer treatments and the body’s own response to cancer. Cancer cells can release cytokines which can be detected by immune cells with the correct receptors. READ MORE