Essays about: "signaling mechanism"
Showing result 1 - 5 of 29 essays containing the words signaling mechanism.
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1. Role of androgen receptor signaling in the activation and differentiation of plasmacytoid dendritic cells
University essay from Göteborgs universitet / Institutionen för biologi och miljövetenskapAbstract : Androgens are steroid hormones essential for the development and maintenance of male reproductive organs and secondary sexual characteristics. Plasmacytoid dendritic cells (pDCs) are immune cells that act as the first line of defense against viral infections. READ MORE
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2. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma
University essay from KTH/ProteinvetenskapAbstract : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. READ MORE
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3. Ligand-stimulated cleavage of PDGFR-beta
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. READ MORE
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4. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics
University essay from Lunds universitet/Institutionen för immunteknologiAbstract : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. READ MORE
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5. Actin filaments as an indicator of impaired neuronal differentiation mediated by disruption of the retinoic acid signalling pathway
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Retinoic acid (RA) is a well-known neurodevelopmental signaling molecule. It is reported to induce effects on neurite formation in differentiating neurons and to interfere with the actin cytoskeleton. Therefore, this project aimed to investigate the mechanisms behind effects of RA on the actin cytoskeleton of developing neurons using the C17. READ MORE