Essays about: "CYP3A4"

Found 4 essays containing the word CYP3A4.

  1. 1. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Rosa Kafey; [2022]
    Keywords : PBPK; MODELLS;

    Abstract : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. READ MORE

  3. 2. Effect of dietary flavonoids on hepatic CYP2E1 and 3A4 activity : implication for food-drug interactions

    University essay from SLU/Dept. of Food Science

    Author : Johanna Östlund; [2017]
    Keywords : cytochrome P450; CYP2E1; CYP3A4; flavonoids; quercetin; myricetin; isorhamnetin; food-drug interactions;

    Abstract : Flavonoids are a group of phytochemicals ubiquitously present in vegetables, fruits, berries and herbs. It is suggested that they contribute to protection against several lifestyle diseases including cancer. READ MORE

  4. 3. Development of an assay for screening drug candidates for mechanism-based inhibition of human CYP3A4

    University essay from Institutionen för livsvetenskaper

    Author : Maria Khihon Rokhas; [2008]
    Keywords : ;

    Abstract : Cytochrome P450 (CYP) constitutes a superfamily of heme- containing enzymes that catalyze the oxidative biotransformation of structurally diverse xenobiotics including pharmaceuticals and drugs. Cytochrome P450 3A4 is not only the most abundant isoform in human liver but is also responsible for metabolizing approximately 60% of therapeutic drugs. READ MORE

  5. 4. Development of a reporter gene assay for PXR mediated CYP3A4 induction

    University essay from Institutionen för fysik, kemi och biologi

    Author : Frank Nylén; [2008]
    Keywords : CYP3A4; induction; reporter gene assay;

    Abstract : PXR mediated elevation of CYP3A4 expression is a costly problem in drug development as well as a clinical problem due to clinically important drug interactions caused by the enzyme induction. CYP3A4 is responsible for the metabolism of more than 50% of the drugs commonly used today. Many of these, as well as other compounds e.g. READ MORE