Essays about: "Huntingtons sjukdom"

Found 4 essays containing the words Huntingtons sjukdom.

  1. 1. Transcriptional basis of Huntington’s Disease: Gene expression analysis indicate increased immune responses in the brain and mitochondrial dysfunction in adipose tissues of HD model mouse

    University essay from KTH/Proteinvetenskap

    Author : Intisar Salim; [2023]
    Keywords : Huntington’s Disease; mRNA-seq; tissue specific gene expression; cerebrospinal fluid; biomarker; Huntingtons sjukdom; mRNA-seq; vävnadsspecifik genexpression; cerebrospinalvätska; biomarkör;

    Abstract : Huntingtons sjukdom (HD) är ett neurodegenerativt tillstånd som orsakas av mutationer i huntingtin gen (Htt), och resulterar till upprepade glutamin (polyQ) i Htt-proteinet. Muterad Htt kan inte vika sig ordentligt och börjar därför aggregera i celler. READ MORE

  3. 2. The anti-amyloidogenic chaperone DNAJB6 and its interaction with other chaperones

    University essay from Lunds universitet/Matematisk statistik; Lunds universitet/Kemiska institutionen

    Author : Gemma Nilsson; [2020]
    Keywords : chaperones; DNAJB6; Hsc70; Hsp110; ATP-hydrolysis; Ab42; polyQ; biochemistry; biokemi; Chemistry;

    Abstract : In order to maintain proteins’ functionality their native folding state must be preserved. Chaperones fold other proteins and DNAJ-chaperones may collaborate with Hsc70 chaperones to prevent aggregation of aggregation-prone peptides such as polyQ and Aβ42, which form fibrils in currently incurable diseases as Huntington’s and Alzheimer’s, respectively. READ MORE

  4. 3. Huntingtin gene profiling, towards allele-specific treatment

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Mimmi Håkansson; [2020]
    Keywords : Huntington’s disease; huntingtin lowering; allele-selective; HD animal models; Huntingtons sjukdom; huntingtin sänkning; allel-specifik; Huntington djurmodeller;

    Abstract : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. READ MORE

  5. 4. Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Maria Arone Blanco; [2018]
    Keywords : Huntington’s disease; Spinocerebellar ataxia; Amyloids; Protein aggregation; Herpes Simplex Virus 1; HSV-1; Virus infection; oligonucleotides; Filter retardation Assay; Dot Blot.; Huntingtons sjukdom; Spinocerebellära ataxier; Amyloider; Protein aggregering; Herpes Simplex Virus 1; HSV-1; Virus infektion; Oligonukleotider; Filter retardation Assay; Dot Blot.;

    Abstract : Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. READ MORE