Essays about: "host cell protein"

Showing result 1 - 5 of 35 essays containing the words host cell protein.

  1. 1. Characterization of Antigenic Properties of Two Immunogenic Proteins of Streptococcus pneumoniae 

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Mawj Jasimalsalih; [2023]
    Keywords : Immunogenic Proteins; PrsA; MalX; Membrane Vesicles; Protein Properties; Streptococcus pneumoniae virulence factors;

    Abstract : The bacterium Streptococcus pneumoniae (pneumococcus), is considered to be a leading cause of morbidity and mortality globally, particularly in infants and the elderly. It is one of the most frequent causes of respiratory tract infections, which sporadically have the potential to develop into serious invasive symptoms including sepsis and meningitis. READ MORE

  3. 2. Development of specific host cell protein assays

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Anna Ivert Nordén; [2023]
    Keywords : Gyrolab; Immunoassay; HCP;

    Abstract : The manufacturing and the development of biotherapeutic drugs involves the expression of biotherapeutic proteins in a host cell expression system followed by a purification process. Bioanalytical methods to measure impurities such as host cell proteins (HCPs) are needed to obtain a robust process and a safe drug according to regulatory requirements. READ MORE

  4. 3. Functional Characterisation of Effectors from Biotrophic and Necrotrophic Wheat Pathogens in Heterologous Expression Systems

    University essay from SLU/Dept. of Forest Mycology and Plant Pathology

    Author : Mark Melchior; [2023]
    Keywords : wheat; Blumeria graminis; Parastagonospora nodorum; effectors;

    Abstract : Effector proteins play an important role in the interactions between fungal pathogens and their host plant. Recognition of effectors can lead to localised cell death in plants. The necrotrophic fungus Parastagonospora nodorum utilises this mechanism to induce cell death in wheat and cause Stagonospora nodorum blotch (SNB). READ MORE

  5. 4. Non-canonical amino acid incorporation as a strategy for labeling membrane bound Na+/K+-ATPase for fluorescence microscopy imaging

    University essay from KTH/Proteinvetenskap

    Author : Adam Johansson Holopainen; [2023]
    Keywords : ncAAs; fluorescence microscopy; amber suppression; nonsense suppression; Na K -ATPase; protein labeling; click chemistry; genetic code expansion; onaturliga aminosyror; fluorescensmikroskopi; Na K -ATPas; proteinmärkning; klickkemi; genetisk kodexpansion;

    Abstract : Natrium-kaliumpumpen spelar en väsentlig roll i en rad fysiologiska funktioner då den upprätthåller den elektrokemiska gradienten över cellmembranet. Ytterligare så är störningar i dess funktion associerade med flera neurologiska sjukdomar. READ MORE

  6. 5. Production, in vitro modification, and interaction analysis of a hydroxyproline-dependent protein

    University essay from Uppsala universitet/Biokemi

    Author : Milica Plavsic; [2023]
    Keywords : protein production optimisation; recombinant expression; bioreactor; prolyl hydroxylase; liquid chromatography mass spectrometry; microscale thermophoresis;

    Abstract : The development of a biologic protein involves different stages and becomes a highly complex process which can be costly and time consuming to scale up for industrial production. Therefore, optimization is a necessary part of the production process development to lower the production expenses. READ MORE