Essays about: "knockdown"

Showing result 1 - 5 of 23 essays containing the word knockdown.

1. 1. Gene expression editing in myeloma cell lines using CRISPR/Cas9 technique

   University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

   Author : Wilma Wadman; [2023]
   Keywords : BMPR1A; BMPR2; bone morphogenetic protein; gene knockout; multiple myeloma;

   Abstract : Multiple myeloma, or myeloma, is a bone marrow cancer which characterizes by uncontrolled proliferation of mutant plasma cells. It is a disease that claims many lives every year, mostly due to the absence of curative treatment. Finding a suitable treatment is therefor of great importance. READ MORE

3. 2. The role of AmotL2 in the regulation of mesenchymal transitioning of endothelial cells

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Author : Anita-Ann Monteiro; [2023]
   Keywords : Endothelial-mesenchymal transition EndMT ; atherosclerosis; transforming growth factor β TGF-β ; Angiomotin-Like 2 AmotL2 ; Scrambled Scr ; knockdown kd ; Immunofluorescence IF ;

   Abstract : Background During development, endothelial cells acquire mesenchymal-like properties to migrate and facilitate normal vascular formation. This process of transformation is known as endothelial to mesenchymal transition (EndMT) and has also been implicated in diseases like vascular pathologies contributing to endothelial inflammation, atherosclerosis and tumour angiogenesis. READ MORE

4. 3. Intracellular Membrane Remodeling Mechanisms Revealed by Cryo-EM

   University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

   Author : Sigrid Mack; [2022]
   Keywords : ;

   Abstract : Endophilin B1 (EnB1) is a BAR protein located in the cytosol that controls membrane dynamics of different organelles such as the mitochondria and the Golgi, as well as autophagosomes. It has been suggested that this protein coordinates membrane remodeling events during essential cell death processes. READ MORE

5. 4. Molecular studies of metronidazole resistance development in Giardia intestinalis

   University essay from Uppsala universitet/Institutionen för cell- och molekylärbiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Christopher Collins; [2022]
   Keywords : Giardia intestinalis; metronidazole;

   Abstract : Giardia intestinalis is a two-staged flagellated protozoan parasite which infects the lumen of the small intestine causing the gastrointestinal disease called giardiasis. This disease infects millions of people per year, commonly caused by inadequate water treatment and proximity to livestock. READ MORE

6. 5. The roles of heparan sulfate in autophagy

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Author : Asifa Khan; [2022]
   Keywords : Heparan sulfate; LC3-II; p62; Autophagy;

   Abstract : Background: Autophagy is a lysosomal degradation process to eliminate damaged components from the cells. It also provides a survival mechanism in stressed conditions and limits growth processes. Heparan sulfate (HS) is a polysaccharide attached to different proteoglycans. READ MORE