Essays about: "Heparan sulfate"

Found 5 essays containing the words Heparan sulfate.

  1. 1. The roles of heparan sulfate in autophagy

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Asifa Khan; [2022]
    Keywords : Heparan sulfate; LC3-II; p62; Autophagy;

    Abstract : Background: Autophagy is a lysosomal degradation process to eliminate damaged components from the cells. It also provides a survival mechanism in stressed conditions and limits growth processes. Heparan sulfate (HS) is a polysaccharide attached to different proteoglycans. READ MORE

  3. 2. Gene expression analysis of fibroblast growth factor in a rat model of human endometrial cancer

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Vipul Chakole; [2018]
    Keywords : ;

    Abstract : The fibroblast growth factor receptor (FGF/FGFR) signaling has a significant role in normal organ development, like vascular and skeletal development. The dysregulation of the fibroblast growth receptor signaling occursdue to genetic modification or over expression of the receptor. This has been observed in different carcinomas [34,35]. READ MORE

  4. 3. Expression of the heparan sulfate biosynthesis enzymes NDST1 and NDST2 and their major splice variants in human tissues.

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Fredrik Kristoffersson; [2018]
    Keywords : Heparan sulfate; NDST; glycobiology; N-Deacetylase And N-Sulfotransferase; NGS; bioinformatics;

    Abstract : The aim of the study was to investigate the expression NDST transcripts in a wide variety of tissues using RNA-sequencing experimental data from five published studies, using two common in silico tools: the Tophat-Cufflink pipeline and the HTSeq-DEXSeq pipeline. We show that to detect NDST alternative transcripts, paired-end sequencing should be used with replicates of samples or conditions together with 100 base read length to allow for reliable detection of the low expressed transcripts in the NDST family. READ MORE

  5. 4. Synthesis towards an aromatic alfa-dixyloside

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Martin Olofsson; [2015]
    Keywords : Synthesis; Proteoglycan; Glucosaminoglycan; Xylose; Carbohydrate; Glycosylation; Organic chemistry; Chemistry;

    Abstract : A proteoglycan is a protein with at least one glycosidic chain or glycosaminoglycan (GAG) covalently bound to it. Since a common linker between the core protein and the GAG chain has a xylose present, the biosynthesis of GAGs can be primed using xylosides containing hydrophobic aglycons providing that these xylosides are capable of penetrating the cell membrane. READ MORE

  6. 5. Effects of overexpression of syndecan-1 in mesenchymal tumor cells

    University essay from Institutionen för livsvetenskaper

    Author : Pamela Grönkvist; [2011]
    Keywords : tumor; molecular cell biology; syndecan; mesenchymal cells;

    Abstract : BackgroundAll cells carry a transmembrane proteoglycan calledsyndecan. Syndecans influence many functions like cell migration, cell adhesionand cell proliferation and it is involved in cellular signaling andtumourigenesis. READ MORE