Essays about: "Biacore"
Showing result 1 - 5 of 15 essays containing the word Biacore.
-
1. Pipeline for Next Generation Sequencing data of phage displayed libraries to support affinity ligand discovery
University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologiAbstract : Affinity ligands are important molecules used in affinity chromatography for purification of significant substances from complex mixtures. To find affinity ligands specific to important target molecules could be a challenging process. Cytiva uses the powerful phage display technique to find new promising affinity ligands. READ MORE
-
2. Development of biophysical methods for characterization of PROTACs
University essay from Uppsala universitet/BiokemiAbstract : Targeting protein with the aim of ubiquitin-labelling for degradation is a new and upand coming field of drug discovery. Proteolysis targeting chimeras (PROTACs) areheterobifunctional linker molecules that connects the target molecule to an E3ubiquitin ligase, subsequent ubiquitination of the target protein initiates the proteindegradation by the proteosome system. READ MORE
-
3. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells
University essay from Linköpings universitet/Institutionen för fysik, kemi och biologiAbstract : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. READ MORE
-
4. Interactions of the Human Recombinant Proteins JUNO and IZUMO1
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Det uppskattas att 15% av alla par världen över lider avinfertilitet. Ungefär hälften beror på manlig infertilitet och 40% av dessa fall kan ännu inte förklaras. Därmed är nuvarande metoder för att diagnostisera manlig infertilitet otillräckliga och ytterligare tekniker behövs. READ MORE
-
5. Development of a label-free biosensor method for the identification of sticky compounds which disturb GPCR-assays
University essay from Institutionen för biologisk grundutbildningAbstract : It is widely known that early estimates about the binding properties of drug candidates are important in the drug discovery process. Surface plasmon resonance (SPR) biosensors have become a standard tool for characterizing interactions between a great variety of biomolecules and it offers a unique opportunity to study binding activity. READ MORE