Essays about: "Galectin-3"

Showing result 1 - 5 of 6 essays containing the word Galectin-3.

  1. 1. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Qrystal Cruz Giron; [2023]
    Keywords : Galectin-3; Galectin-3 inhibitor; 1-phenylethanol; C2 threitol derivative; galactose-mimicking inhibitor; organic chemistry; Chemistry;

    Abstract : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. READ MORE

  3. 2. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Simon Birgersson; [2019]
    Keywords : Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

    Abstract : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. READ MORE

  4. 3. Synthesis of 3-azido-2,4,6-tri-O-(4-methoxybenzyl)-3-deoxy-galactopyranoside

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Esbjörn Reistad; [2019]
    Keywords : Medicinal chemistry; Cancer; macrocyclization; Organic chemistry; Chemistry;

    Abstract : Galectin-3 is a protein that is involved in many physiological processes such as metastasis, T-cell regulation etc. which makes it a good drug target for the medicinal chemist. READ MORE

  5. 4. Synthesis of fluorescent carbohydrate coumarin hybrids via a three-component reaction : nanomolar galectin-3 inhibitor

    University essay from Lunds universitet/Kemiska institutionen

    Author : Shaun Hoang; [2013]
    Keywords : Organisk kemi; Chemistry;

    Abstract : Galectins play an important role in inflammation, immunity, cancer progression and are potential targets for novel anti-cancer and anti-inflammatory compounds. Coumarin thiodigalacoside hydrid had proved to be potent, nanomolar, and selective inhibitor of galectin-3. READ MORE

  6. 5. Synthesis of 3-C-(4-aryl-5-halo-1,2,3-triazol-1-yl)-galactosides: Probing halogen bonding in galectin-ligand complexes

    University essay from Lunds universitet/Kemiska institutionen

    Author : Marcus Ljungberg; [2011]
    Keywords : Organisk kemi; Chemistry;

    Abstract : The continued search for compounds exhibiting a better inhibition of Galectin-3 and -1 has been performed in this thesis. It has been shown that the Galectins are over-expressed in cancer cells and play an important role in inflammatory conditions connected to apoptosis (cell death). READ MORE