Essays about: "Cysteine"

Showing result 1 - 5 of 47 essays containing the word Cysteine.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    University essay from Uppsala universitet/Theranostics

    Author : Astrid Haraldsson; [2023]
    Keywords : PNA; pretargeting; cancer therapy; cytotoxic payload;

    Abstract : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. READ MORE

  3. 2. Studies of broad-spectrum inhibitors against main protease of SARS-CoV-2 and other Coronaviruses

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Alexandra Stanciu; [2023]
    Keywords : human coronavirus 229E; SARS-CoV-2; main protease; nirmatrelvir; GC-376; compound 19;

    Abstract : Coronaviruses have caused three large outbreaks in the past century. The most recent one, also still ongoing, is represented by the SARS-CoV-2/Covid-19 pandemic. Efforts have been taken to develop efficient vaccines and antivirals and one of the major virus-based targets in drug development is represented by the main protease of these viruses. READ MORE

  4. 3. Production and analysis of novel disulfide variants of Subtilisin Carlsberg

    University essay from Linköpings universitet/Kemi

    Author : Anton Elfstrand; [2023]
    Keywords : Subtilisin Carlsberg; Disulfide; Protein Engineering; Kinetic Stability;

    Abstract : Protein engineering has been used to alter the stability of proteins for several decades withmuch success, one approach being to introduce two cysteine residues that together form adisulfide bridge. The disulfide bridge can increase the Gibbs free energy of the transitionstate, thus increasing energy difference between the folded state and the unfolding transitionstate, leading to increased kinetic stability of the protein. READ MORE

  5. 4. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Elin Öberg; [2022]
    Keywords : x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Abstract : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. READ MORE

  6. 5. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    University essay from Uppsala universitet/Institutionen för kemi - BMC

    Author : Carita Hammar; [2022]
    Keywords : ;

    Abstract : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. READ MORE