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Showing result 1 - 5 of 6 essays matching the above criteria.

1. 1. Design and production of adeno-associated virus vectors for imaging mitochondrial networks in the brain

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Elnaz Samadian Zad; [2023]
   Keywords : adeno-associated virus; mitochondria; mitochondrial networks; imaging; fluorescent protein; synapsin promoter; human embryonic kidney cells; organoids;

   Abstract : Mitochondria are dynamic organelles that function in a complex interconnected network within the cell. Neurons are sensitive and highly energy demanding cells in the brain which require a functioning mitochondrial network that is able to provide ATP and modulate calcium. READ MORE

3. 2. Automated pipeline for processing fluorescence calcium imaging microscopy data and electrophysiological measurements from 3D brain organoids

   University essay from Lunds universitet/Examensarbeten i bioinformatik

   Author : Mattis Knulst; [2021]
   Keywords : Biology and Life Sciences;

   Abstract : Motivation: 3D brain organoids are biological models of human brain development from which a rich body of data can be extracted that allows for insights about neuronal dynamics. Several tools, such as fluorescence calcium imaging microscopy and electrophysiological recordings are being used to assess how 3D brain organoid dynamics recapitulate what is known from the human brain. READ MORE

4. 3. Tuning the crosslinking chemistry for self-healable mucin hydrogel synthesis and application

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Francesca Pacella; [2020]
   Keywords : Mucin; Hydrogel; Click-chemistry; Characterization; Self-healing; Injectable; Hydrogeler; Mucin; självhelande;

   Abstract : Immune-orchestrating biomaterials that precisely modulate the immune reac-tion to the host could lead the way for improving the implantation outcomein the transplantation field, in comparison to passive biomaterials. The lab-oratory of Dr. READ MORE

5. 4. Patient-derived organoid culture for 3D culture of colorectal cancer, renal cancer and osteosarcoma

   University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Author : Seiko Johansson; [2019]
   Keywords : FMCA; Anticancer drugs; Survival index; BME-gel; VEGF;

   Abstract : It is always important to choose appropriate anticancer drugs for cancer patients. At RCL, a division of Uppsala university hospital, drug resistance profiles of patients are evaluated by a cell viability assay called FMCA. READ MORE

6. 5. Intestinal epithelial organoid gene expression and the effects of SalmonellaTyphimurium invasion

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Author : Labolina Spång; [2019]
   Keywords : Non-typhoidal Salmonella; salmonellosis; intestinal organoids; gene expression analysis; real-time qPCR;

   Abstract : Salmonella species are one of the leading causes of diarrhea world-wide, and the details regarding their pathogenicity is not yet completely understood. In order to understand the interactions that occur during the invasion of the gut intestine we aimed to explore the use of intestinal epithelial organoids as a model to study the infection process of Salmonella enterica subspecies enterica serotype Typhimurium. READ MORE