A REVIEW ON THE ROLE OF A SELECTION OF BISPHENOLS IN ADIPOGENESIS

Abstract: Obesity is a growing global problem, and it is now considered to be a health problem with epidemic status. The condition is associated with several serious comorbidities, such as cardiovascular diseases and type 2 diabetes mellitus. This makes it highly relevant to seek for solutions to the obesity issue. Diet and exercise are two important components in the area, but studies are also indicating exposure to chemicals so called obesogens, could contribute as well. Bisphenols are chemicals we are frequently exposed to in our every-day environment, mostly through plastics. In this project, the adipogenic effects from a relevant selection of 8 different bisphenols in vitro were examined by a thorough literature search on published data. Concluding results from this research indicated that the structural analogues of BPA appear to be as problematic as BPA with respect to adipogenesis, and should be used with caution. It was also clearly demonstrated that further studies are needed in order to gain more data and understand their adipogenic impact.