Essays about: "Protein-Protein Interaction Networks"

Found 5 essays containing the words Protein-Protein Interaction Networks.

  1. 1. Gene Biomarker Identification by Distinguishing Between Small-Cell and Non-Small Cell Lung Cancer Through a Module-Based Approach

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Noor Haval Jamal; [2023]
    Keywords : ;

    Abstract : Lung cancer is the leading cause of cancer-related deaths worldwide and is divided into two broad histological types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Network module-based approach is applied to lung cancer subtypes in order to analyze and compare the results with previous literature and thus discover new genetic biomarkers and/or confirm previously discovered ones. READ MORE

  2. 2. The Effect of Interactive Selection on Personalized Drug Prediction Using Interactomes : Examination of Parameters Impacting Drug Treatment Rankings from Network Models for Covid-19 Patients

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Cornelia Torell; [2023]
    Keywords : Precision Medicine; Pharmacogenomics; Biomarkers; Covid-19; Digital Twins; Network Modeling; Interactomes; Protein-Protein Interaction Networks; Differentially Expressed Genes; Principal Coordinate Analysis; Precisionsmedicin; Farmakogenetik; Biomarkörer; Covid-19; Digitala tvillingar; Nätverksmodellering; Interaktom; Proteininteraktionsnätverk; Sjukdomsrelaterade gener; Principalkoordinatanalys;

    Abstract : Patients not responding to therapy as expected is one of the most pressing healthcare concerns of today. It causes economical, medical and societal issues along with suffering for patients. This project aimed to address this problem and evaluate how to find the best suited drug treatments for individual patients to treat Covid-19. READ MORE

  3. 3. Capturing genes with high impact based on reconstruction errors produced by variational autoencoders

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Utz Lovis Rieger; [2023]
    Keywords : ;

    Abstract : In this work we present a novel method to extract potential hub genes, transcription factors and regions with densely interconnected protein-protein-interaction networks from RNAseq data. To achieve this we deploy variational autoencoders, a generative machine learning framework, and extract the gene-wise reconstruction errors. READ MORE

  4. 4. Protein-protein interactions with and within the NLRP3 inflammasome : Evidence from STRING and literature studies

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Ralph Monte; [2020]
    Keywords : ;

    Abstract : Inflammasomes are multiprotein complexes that play a role in the innate immune system. One inflammasome is the NLRP3 inflammasome, which can be activated and primed by different stimuli that bind to pattern recognition receptors (PRRs). READ MORE

  5. 5. Protein-Protein Docking Using Starting Points Based On Structural Homology

    University essay from Linköpings universitet/Bioinformatik

    Author : Martin Hyvönen; [2015]
    Keywords : In silico; Rosetta Dock; Bound docking; PPI; Bioinformatics; InterPred;

    Abstract : Protein-protein interactions build large networks which are essential in understanding complex diseases. Due to limitations of experimental methodology there are problems with large amounts of false negative and positive interactions; and a large gap in the amount of known interactions and structurally determined interactions. READ MORE