Essays about: "pharmacometric models"

Found 5 essays containing the words pharmacometric models.

1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Johan Borg; [2023]
   Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

   Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

3. 2. Pharmacometric model of Glucagon-ACTH-Cortisol in hyperinsulineamiceu/hypoglycaemic and hyperglycemicclamps in individuals who are lean andobese

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Reem Emad Muhanad; [2021]
   Keywords : ;

   Abstract : Introduction: Type 2 diabetes (T2D) increases in prevalence and generates significant diseaseburden, where impairment in hormonal systems, such as glucagon, is suspected to contribute to T2Ddevelopment. Covariates such as obesity is a known risk factor for T2D development. READ MORE

4. 3. Predictability and performance of different non-linear mixed-effects models for HbA1c in patients with type 2 diabetes mellitus

   University essay from Institutionen för farmaceutisk biovetenskap; Institutionen för biologisk grundutbildning

   Author : Gustaf Wellhagen; [2014]
   Keywords : Type 2 diabetes mellitus; semi-mechanistic models; HbA1c; glucose; insulin; NONMEM;

   Abstract : To accurately predict the outcome of a late phase study, pharmacometric models can help in drug development. Making informed decision on which models to use will also facilitate drug development. This can depend on the mechanism of action for the drug as well as stability and runtime factors. READ MORE

5. 4. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa

   University essay from Institutionen för farmaceutisk biovetenskap

   Author : Jonathan Lyly; [2011]
   Keywords : meropenem; colistin; pseudomonas aeruginosa; models; pharmacometric models; pharmacokinetic models; PKPD;

   Abstract : Resistant bacteria are becoming more and more of a problem but treatment with antibiotics in combination may overcome and prevent resistance development. The combination of meropenem and colistin against Pseudomonas aeruginosa has been proposed as a promising treatment to increase the bactericidal effect and a synergistic effect has been proposed. READ MORE

6. 5. Faster Optimal Design Calculations for Practical Applications

   University essay from Institutionen för farmaceutisk biovetenskap

   Author : Eric Strömberg; [2011]
   Keywords : Optimal Design; PopED; pharmacometrics; pharmacokinetics; pharmacodynamics; Fisher Information Matrix; parallelization;

   Abstract : PopED is a software developed by the Pharmacometrics Research Group at the Department of Pharmaceutical Biosiences, Uppsala University written mainly in MATLAB. It uses pharmacometric population models to describe the pharmacokinetics and pharmacodynamics of a drug and then estimates an optimal design of a trial for that drug. READ MORE