Essays about: "Drug Discovery"

Showing result 16 - 20 of 80 essays containing the words Drug Discovery.

1. 16. Expanding the application of a novel proteomics tool for drug target and mechanism identification

   University essay from Uppsala universitet/Analytisk kemi

   Author : Linnéa Yuan Andersson; [2022]
   Keywords : ;

   Abstract : In drug discovery and development, characterization of the drug targets and mechanisms of action is an essential step. ProTargetMiner is a publicly available proteome signature library of anticancer molecules and its automated bioinformatics platform can be used for drug target and mechanism deconvolution. READ MORE

3. 17. ProTargetMiner one step further : Deep comparative proteomics of Dying vs. Surviving cancer cells treated with anticancer compounds

   University essay from Uppsala universitet/Analytisk kemi

   Author : Albin Lundin; [2022]
   Keywords : Cancer; Surviving VS Dying; Proteomics; Comparative Proteomics; RKO; A549; MCF7; drug discovery; life; death; life and death decisions; target ranking; OPLS-DA; drug targets; novel anticancer agents;

   Abstract : Cancer is a leading cause of mortality worldwide, responsible for nearly one in six deaths. Thus, there is a need for a greater understanding of cancer for the development of novel therapeutics. This master thesis project aims to compare the proteome signatures between dying and surviving cancer cells treated with diverse anticancer drugs. READ MORE

4. 18. In Vitro Assessment of Novel Compounds as Potential Pan-Coronavirus Therapeutics in SARS-CoV-2 and In Vitro Assessment of a Pan-Flavivirus Compound in Zika Virus

   University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Author : Julia Berger; [2022]
   Keywords : Human coronavirus; active protease inhibitors; drug discovery; 3CLpro; Zika virus; flavivirus inhibitor; NS2B-NS3;

   Abstract : Through the SARS-CoV-2 pandemic, it has become clear that the development of antivirals is essential for the health and wellbeing of the population. In this study, novel active site protease inhibitors against SARS-CoV-2 were tested for their inhibitory activity against the viral 3-Chymotrypsin like protease through the means of FRET based enzymatic assays. READ MORE

5. 19. The differential signalling of the succinate receptor SUCNR1/GPR91, through Gi versus Gq

   University essay from Lunds universitet/Teknisk mikrobiologi

   Author : Sofie Liljewall; [2022]
   Keywords : GPR91; SUCNR1; G protein recruitment; Gi; Gq; TRUPATH biosensor; BRET2; Applied Microbiology; Biology and Life Sciences;

   Abstract : G protein-coupled receptors are the biggest family of membrane bound receptor in the human genome, they are also target for many drugs due to their accessible location in the cell membrane. We have characterized the G protein recruitment of the succinate receptor 1 (SUCNR1/GPR91). READ MORE

6. 20. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

   University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

   Author : Marc Pielies Avellí; [2022]
   Keywords : Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

   Abstract : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. READ MORE