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Found 5 essays matching the above criteria.
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1. Approaches to Structural Characterization of a Heteromeric GABA(A)R
University essay from KTH/Tillämpad fysikAbstract : Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. READ MORE
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2. Modulation of a model ligand-gated ion channel by amphetamine derivatives
University essay from Uppsala universitet/StrukturbiologiAbstract : Pentameric ligand-gated ion channels are critical mediators of electrochemical signal transduction in neurons and other excitable cells, causing them to be important targets of psychoactive drugs. Structural data for these complex proteins are limited, particularly among eukaryotic family members and for the functionally critical open state. READ MORE
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3. Extraction of gating mechanisms from Markov state models of a pentameric ligand-gated ion channel
University essay from KTH/ProteinvetenskapAbstract : GLIC är en pH-känslig pentamerisk ligandstyrd jonkanal (pLGIC) som finns i cellmembranet hos prokaryoten Gloeobacter violaceus. GLIC är en bakteriell homolog till flera receptorer som är viktiga i nervsystemet hos de flesta eukaryotiska organismer. READ MORE
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4. Characterization of Alcohol Modulation of a Pentameric Ligand-gated Ion Channel with Electrophysiology and Molecular Dynamics Simulations
University essay from KTH/Tillämpad fysikAbstract : Pentameric ligand-gated ion channels (pLGICs) are membrane receptors that play a crucial role in every living organism. The pLGIC protein structure forms a pore through the membrane of a cell that can let specific ions pass through, upon activation by endogenous agonists. READ MORE
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5. Structural basis of modulation by pH and calcium in a ligand-gated ion channel
University essay from KTH/GenteknologiAbstract : Pentameriska ligandstyrda jonkanaler (pLGICs) är avgörande för omvandlingen av kemisk till elektrisk signalöverföring i djurs nervsystem. Dysfunktion i dessa kanaler har visat sig vara kopplad till flera sjukdomar inklusive epilepsi, schizofreni, Alzheimers och autism, vilket gör dem till en måltavla för en mängd olika läkemedel. READ MORE